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SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
USERS' SCORE
Good
Based on 1 Reviews
8
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Turmeric ExtractCurcuma longa (Rhizome)(95% [475 mg] Total Curcuminoids)
500 mg
†
Top Medical Research Studies
9
Curcumin reduces MS-related inflammation
Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis.
Highly relevant to MS treatment
We set out to understand how curcumin, a compound found in turmeric, and its modified version, F-curcumin, impact cytokine levels in mouse models of multiple sclerosis (MS). In our research, we focused on autoimmune encephalomyelitis (EAE), a model that closely mimics MS, examining how these compounds affect various cytokines that play key roles in inflammation and immune responses in the central nervous system.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
Read More
9
Curcumin shows promise for MS
Curcumin's spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses.
Highly relevant to MS treatment
We investigated how curcumin, a compound derived from turmeric, might help alleviate symptoms of multiple sclerosis (MS) in a mouse model. By using female C57BL/6 mice, we induced experimental autoimmune encephalomyelitis (EAE)—a common animal model for MS—and treated them with oral doses of curcumin at 100 and 200 mg/kg starting right after the EAE induction.
Our findings were promising, showing that both doses of curcumin significantly slowed down the progression of EAE. We noticed reduced infiltration of harmful leukocytes into the central nervous system, which is crucial since excessive inflammation contributes to the damage seen in MS. Furthermore, curcumin appeared to promote the secretion of beneficial cytokines from specific immune cells while decreasing pro-inflammatory markers, creating a more balanced immune response.
Additionally, curcumin influenced the expression of various transcription factors linked to regulatory and helper T cells, further suggesting that it can help shift immune responses toward a more protective state. Overall, our results support the idea that curcumin could serve as a therapeutic option for managing MS, highlighting its potential to improve the quality of life for individuals affected by this challenging condition.
Our findings were promising, showing that both doses of curcumin significantly slowed down the progression of EAE. We noticed reduced infiltration of harmful leukocytes into the central nervous system, which is crucial since excessive inflammation contributes to the damage seen in MS. Furthermore, curcumin appeared to promote the secretion of beneficial cytokines from specific immune cells while decreasing pro-inflammatory markers, creating a more balanced immune response.
Additionally, curcumin influenced the expression of various transcription factors linked to regulatory and helper T cells, further suggesting that it can help shift immune responses toward a more protective state. Overall, our results support the idea that curcumin could serve as a therapeutic option for managing MS, highlighting its potential to improve the quality of life for individuals affected by this challenging condition.
Read More
8
Curcumin shows promise in MS
Curcumin ameliorates astrocyte inflammation through AXL in cuprizone-induced mice.
Highly relevant to MS treatment
Our investigation focused on understanding how curcumin, a compound derived from turmeric, impacts multiple sclerosis (MS) by investigating its effects on astrocytes, the supportive cells in the brain. We explored the use of curcumin in mice with cuprizone-induced demyelination, a model that mimics MS. Our study aimed to reveal whether curcumin could improve myelin loss and inflammatory responses associated with this condition.
We observed that when treated with curcumin, the mice showed a significant reduction in myelin loss and a decrease in astrocyte activation, particularly in the corpus callosum area of the brain. Additionally, in tests involving primary astrocytes stimulated with lipopolysaccharide to induce inflammation, curcumin demonstrated the ability to bring down inflammation levels.
Furthermore, our findings suggest that curcumin's neuroprotective effects may be connected to AXL, a receptor involved in regulating astrocyte-mediated inflammation. This insight opens doors for potential targeted treatments for MS patients, highlighting curcumin's promise as an anti-inflammatory agent in neurological disorders.
We observed that when treated with curcumin, the mice showed a significant reduction in myelin loss and a decrease in astrocyte activation, particularly in the corpus callosum area of the brain. Additionally, in tests involving primary astrocytes stimulated with lipopolysaccharide to induce inflammation, curcumin demonstrated the ability to bring down inflammation levels.
Furthermore, our findings suggest that curcumin's neuroprotective effects may be connected to AXL, a receptor involved in regulating astrocyte-mediated inflammation. This insight opens doors for potential targeted treatments for MS patients, highlighting curcumin's promise as an anti-inflammatory agent in neurological disorders.
Read More
Most Useful Reviews
3.5
No effect noted
Not suitable for everyone. I have multiple sclerosis and gastrointestinal issues. After an exacerbation, I experienced muscle pain and frequent headaches. I began taking curcumin, starting with one tablet. After two weeks with no effect, I increased to two tablets and no longer needed NSAIDs, but I developed diarrhoea. They also mention potential side effects such as kidney stones and iron deficiency. Unfortunately, the drug did not suit me.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 15 Researches
7.9
9
Curcumin supports testicular health in MS
The ameliorative effects of curcumin nanomicelle on testicular damage in the mouse model of multiple sclerosis.
Examines turmeric's impact on MS
We explored how curcumin nanomicelle (CUR-n) could affect testicular function and hormonal balance in a mouse model of multiple sclerosis (MS). Our investigation involved twenty-four male C57BL/6 mice, which we divided into four groups. One group received a diet containing 2% cuprizone (CPZ), a substance known to induce MS-like symptoms. The other groups received the same diet but with different doses of CUR-n: 50 mg/kg and 100 mg/kg.
The results revealed some exciting findings. We observed that the higher dose of CUR-n significantly increased levels of hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone. Additionally, it improved total antioxidant capacity while reducing markers of oxidative stress. We found that CUR-n also encouraged the growth of various cell types important for sperm development, leading to better sperm count, viability, and motility.
Notably, we saw considerable improvements in testicular weight and structure, with reduced damage to the germinal epithelium. These outcomes suggest that CUR-n has the potential to alleviate some adverse effects of MS on testicular health. Overall, our study indicates that curcumin nanomicelle could be a promising therapeutic option for those affected by multiple sclerosis.
The results revealed some exciting findings. We observed that the higher dose of CUR-n significantly increased levels of hormones such as luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone. Additionally, it improved total antioxidant capacity while reducing markers of oxidative stress. We found that CUR-n also encouraged the growth of various cell types important for sperm development, leading to better sperm count, viability, and motility.
Notably, we saw considerable improvements in testicular weight and structure, with reduced damage to the germinal epithelium. These outcomes suggest that CUR-n has the potential to alleviate some adverse effects of MS on testicular health. Overall, our study indicates that curcumin nanomicelle could be a promising therapeutic option for those affected by multiple sclerosis.
Read More
9
Curcumin reduces MS-related inflammation
Curcumin and Its Semisynthetic Derivative F-Curcumin Ameliorate the Expression of Cytokines in Autoimmune Encephalomyelitis Mouse Models of Multiple Sclerosis.
Highly relevant to MS treatment
We set out to understand how curcumin, a compound found in turmeric, and its modified version, F-curcumin, impact cytokine levels in mouse models of multiple sclerosis (MS). In our research, we focused on autoimmune encephalomyelitis (EAE), a model that closely mimics MS, examining how these compounds affect various cytokines that play key roles in inflammation and immune responses in the central nervous system.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
Our findings revealed that both curcumin and F-curcumin significantly reduced the severity and onset of EAE. Notably, these compounds led to a marked drop in the expression of several pro-inflammatory cytokines, such as IL-1, IFN-γ, and IL-17, while boosting the levels of anti-inflammatory cytokines like TGF-β and IL-10. This shift suggests a potential for curcumin and F-curcumin to balance the immune response, which is crucial in managing MS.
Interestingly, the effects were more pronounced with F-curcumin, indicating that our modified version may offer enhanced benefits for inflammatory conditions like MS. Overall, this study highlights the promise of curcumin and its derivatives as potential therapeutic agents in mitigating inflammation associated with multiple sclerosis.
Read More
9
Curcumin shows promise for MS
Curcumin's spice-infused therapeutic promise: disease severity alleviation in a mouse model of multiple sclerosis via modulation of immune responses.
Highly relevant to MS treatment
We investigated how curcumin, a compound derived from turmeric, might help alleviate symptoms of multiple sclerosis (MS) in a mouse model. By using female C57BL/6 mice, we induced experimental autoimmune encephalomyelitis (EAE)—a common animal model for MS—and treated them with oral doses of curcumin at 100 and 200 mg/kg starting right after the EAE induction.
Our findings were promising, showing that both doses of curcumin significantly slowed down the progression of EAE. We noticed reduced infiltration of harmful leukocytes into the central nervous system, which is crucial since excessive inflammation contributes to the damage seen in MS. Furthermore, curcumin appeared to promote the secretion of beneficial cytokines from specific immune cells while decreasing pro-inflammatory markers, creating a more balanced immune response.
Additionally, curcumin influenced the expression of various transcription factors linked to regulatory and helper T cells, further suggesting that it can help shift immune responses toward a more protective state. Overall, our results support the idea that curcumin could serve as a therapeutic option for managing MS, highlighting its potential to improve the quality of life for individuals affected by this challenging condition.
Our findings were promising, showing that both doses of curcumin significantly slowed down the progression of EAE. We noticed reduced infiltration of harmful leukocytes into the central nervous system, which is crucial since excessive inflammation contributes to the damage seen in MS. Furthermore, curcumin appeared to promote the secretion of beneficial cytokines from specific immune cells while decreasing pro-inflammatory markers, creating a more balanced immune response.
Additionally, curcumin influenced the expression of various transcription factors linked to regulatory and helper T cells, further suggesting that it can help shift immune responses toward a more protective state. Overall, our results support the idea that curcumin could serve as a therapeutic option for managing MS, highlighting its potential to improve the quality of life for individuals affected by this challenging condition.
Read More
9
Curcumin aids multiple sclerosis therapy
Dual Mechanism of Action of Curcumin in Experimental Models of Multiple Sclerosis.
Significant for MS treatment exploration
We explored the potential of curcumin, a compound found in turmeric, as a treatment for multiple sclerosis (MS) by examining both in vitro and in vivo models. The research aimed to understand how curcumin affects the inflammatory and demyelination processes associated with MS, a condition marked by significant neurological challenges.
In our in vitro tests, we noted that curcumin enhanced cell proliferation and influenced the production of certain cytokines, which are crucial in the immune response. We then moved on to two experimental models: the cuprizone model to assess myelination effects and the experimental autoimmune encephalomyelitis (EAE) model for immune-related changes. The results were promising, showing that curcumin helped reduce neurological symptoms in EAE and positively influenced immune markers in the spinal cord.
Additionally, curcumin seemed to support motor function and improve myelination in demyelinated mice, demonstrated by better scores in terms of myelin staining. Overall, our study suggests that curcumin could be a valuable therapeutic agent in addressing the neuroimmune issues and demyelination seen in MS through its anti-inflammatory and antioxidant properties.
In our in vitro tests, we noted that curcumin enhanced cell proliferation and influenced the production of certain cytokines, which are crucial in the immune response. We then moved on to two experimental models: the cuprizone model to assess myelination effects and the experimental autoimmune encephalomyelitis (EAE) model for immune-related changes. The results were promising, showing that curcumin helped reduce neurological symptoms in EAE and positively influenced immune markers in the spinal cord.
Additionally, curcumin seemed to support motor function and improve myelination in demyelinated mice, demonstrated by better scores in terms of myelin staining. Overall, our study suggests that curcumin could be a valuable therapeutic agent in addressing the neuroimmune issues and demyelination seen in MS through its anti-inflammatory and antioxidant properties.
Read More
9
Curcumin may aid demyelination
Conjugated Linoleic Acid-Curcumin Attenuates Cognitive Deficits and Oxidative Stress Parameters in the Ethidium Bromide-Induced Model of Demyelination.
Study highlights curcumin's benefits
We investigated how curcumin, a compound found in turmeric, affects cognitive function in the context of multiple sclerosis (MS). Using a group of adult male Wistar rats, we induced MS through ethidium bromide and then treated different groups with curcumin alone or combined with conjugated linoleic acid.
Over five days, we observed notable improvements in spatial memory and a reduction in oxidative stress markers among the rats that received curcumin and its combination with conjugated linoleic acid, particularly at higher doses. This suggests that enhancing the bioavailability of curcumin with another compound can offer better results in managing cognitive deficits associated with demyelination, common in MS.
While curcumin on its own has some challenges due to poor absorption, our study highlights the potential of using modified forms, such as Lino-CUR, to make it a more effective treatment option. Overall, our findings indicate that this combination therapy could be a promising avenue for further exploration in treating the impacts of MS.
Over five days, we observed notable improvements in spatial memory and a reduction in oxidative stress markers among the rats that received curcumin and its combination with conjugated linoleic acid, particularly at higher doses. This suggests that enhancing the bioavailability of curcumin with another compound can offer better results in managing cognitive deficits associated with demyelination, common in MS.
While curcumin on its own has some challenges due to poor absorption, our study highlights the potential of using modified forms, such as Lino-CUR, to make it a more effective treatment option. Overall, our findings indicate that this combination therapy could be a promising avenue for further exploration in treating the impacts of MS.
Read More
User Reviews
USERS' SCORE
Good
Based on 1 Reviews
8
3.5
No effect noted
Not suitable for everyone. I have multiple sclerosis and gastrointestinal issues. After an exacerbation, I experienced muscle pain and frequent headaches. I began taking curcumin, starting with one tablet. After two weeks with no effect, I increased to two tablets and no longer needed NSAIDs, but I developed diarrhoea. They also mention potential side effects such as kidney stones and iron deficiency. Unfortunately, the drug did not suit me.
Read More
